Interaction between aging and syndrome X: new insights on the pathophysiology of fat distribution.

@article{Barzilai1999InteractionBA,
  title={Interaction between aging and syndrome X: new insights on the pathophysiology of fat distribution.},
  author={Nir Barzilai and G Gupta},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={892},
  pages={58-72}
}
Increased fat mass (FM), and in particular a specific increase in visceral fat (VF), may account for the age-associated decrease in insulin action and the development of Syndrome X. Utilizing chronic caloric restriction (CR) with aging in a rodent model, we dissociated the effects of VF and FM, and demonstrated that the decrease in VF accumulation was sufficient to prevent the marked decrease in hepatic insulin action. This suggests that the typical increase in VF with aging, rather than aging… CONTINUE READING

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