Interaction between a heme oxygenase-1 gene promoter polymorphism and serum beta-carotene levels on 8-year lung function decline in a general population: the European Community Respiratory Health Survey (France).

@article{Gungou2008InteractionBA,
  title={Interaction between a heme oxygenase-1 gene promoter polymorphism and serum beta-carotene levels on 8-year lung function decline in a general population: the European Community Respiratory Health Survey (France).},
  author={Armelle Gu{\'e}n{\'e}gou and Jorge Boczkowski and Michel Aubier and Françoise Neukirch and B{\'e}n{\'e}dicte Leynaert},
  journal={American journal of epidemiology},
  year={2008},
  volume={167 2},
  pages={139-44}
}
Oxidative stress is thought to play a major role in the pathogenesis of chronic obstructive pulmonary disease, characterized by impaired lung function. A large number (> or =33) of GT repeats (L-allele) in the gene of the powerful antioxidant enzyme heme oxygenase-1 has been associated with susceptibility to accelerated lung function decline. In contrast, beta-carotene may help to protect against accelerated decline. To determine whether high serum levels of beta-carotene might counterbalance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

GOLD, Lung Health Center, University of Alabama, 2006

  • Global Initiative for Chronic Obstructive Lung Disease. G diagnosis, management, AL prevention of chronic obstructive pulmonary diseas Birmingham
  • (http://www.goldcopd.com/GuidelinesResources.asp…
  • 2007
1 Excerpt

World Health Organization, 2007

  • WHO Regional Office for Europe. Tobacco control databa Geneva, Switzerland
  • (http://data.euro.who.int/tobacco/).
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…