Interaction between Warfarin and Danshen (Salvia Miltiorrhiza)

@inproceedings{Chan2001InteractionBW,
  title={Interaction between Warfarin and Danshen (Salvia Miltiorrhiza)},
  author={Thomas Yan Keung Chan},
  booktitle={The Annals of pharmacotherapy},
  year={2001}
}
  • T. Y. Chan
  • Published in The Annals of pharmacotherapy 2001
  • Medicine
OBJECTIVE: To discuss the potential for an adverse interaction between the Chinese herb danshen, the dry root and rhizome of Salvia miltiorrhizaBge, and warfarin. DATA SOURCES: A MEDLINE search was performed (from January 1966 through October 2000) using the key words danshen and Salvia miltiorrhiza. All articles written in English or with an English extract were considered for review. STUDY SELECTION AND DATA EXTRACTION: All studies of antithrombotic effects of danshen or interaction between… Expand
Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes
TLDR
It can be concluded that precautions should be taken when using Danshen preparations rich in tanshinones for CYP-related herb-drug interactions, and the metabolism and pharmacokinetics that are related to these interactions. Expand
Radix Puerariae lobatae (Gegen) suppresses the anticoagulation effect of warfarin: a pharmacokinetic and pharmacodynamics study
TLDR
Gegen, rather than Danshen at the same tested dosage, offsets the anticoagulant effects of warfarin by accelerating the phase I liver metabolism of warFarin, as well as increasing the activity, mRNA and protein expression of VKOR while decreasing those of TM. Expand
Bleeding due to a probable interaction between warfarin and Gouqizi (Lycium Barbarum L.)
TLDR
It is illustrated that large doses (more than 6–12 g) of Gouqizi can significantly enhance the anticoagulant action of warfarin and may cause similar adverse effects in keeping with three previous reports. Expand
Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin.
TLDR
It has been proven by ex vivo study that the single-dose administration of DGF could decrease the protein binding of warfarin in plasma by at least 11.6% and the inductive effects of D GF on the liver phase I metabolism of warFarin may be dominantly responsible for the DGF-warfarin pharmacokinetics interactions. Expand
Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use
TLDR
Although numerous clinical trials have demonstrated that certain Danshen products in China are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality and large randomized clinical trials and further scientific research are necessary to ensure the safety, effectiveness, and better understanding of its action. Expand
Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation.
TLDR
High performance liquid chromatography analysis of the plasma of rats received SA, NG or combination of SA and NG showed that co-administration of NG caused change in the plasma distribution profile of SA, suggesting that the influence of combination on the absorption and/or metabolism of SA may be one of the reasons for the synergism ofSA and NG in vivo. Expand
Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo.
  • Windy W P Wu, J. Yeung
  • Chemistry, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2010
TLDR
The results suggest that tanshinones inhibited CYP1A1, CYP2C6 and CYP 2C11-mediated warfarin metabolism both in vitro and in vivo in the rats. Expand
Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers.
TLDR
Danshen extract does not influence the metabolism of theophylline in healthy volunteers and hence may not be necessary in patients receiving concurrent therapy with danshen Extract tablets, and the pharmacokinetics parameter of thephylline was unaffected by dansen extract. Expand
Revieweffects of Salvia miltiorrhiza (Danshen) on cerebral infarction
TLDR
Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Expand
Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction
TLDR
Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
The Effects of Danshen (Salvia miltiorrhiza) on Warfarin Pharmacodynamics and Pharmacokinetics of Warfarin Enantiomers in Rats
The effects of Danshen (Salvia miltiorrhiza), a popular traditional Chinese medicinal herb on the pharmacokinetics and pharmacodynamics of R‐ and S‐warfarin stereoisomers were studied in rats.
[Antithrombotic and antiplatelet effects of rosmarinic acid, a water-soluble component isolated from radix Salviae miltiorrhizae (danshen)].
TLDR
The results that Ros A showed mild antithrombotic effect might be related to its inhibition of platelet aggregation and promotion of fibrinolytic activity. Expand
[Effects of different administration of Salvia miltiorrhiza and heparin on antithrombin IIIAg, antithrombin III: A and alpha 2-macroglobulin in patients with cor pulmonale].
  • F. Zhang, L. J. Zheng
  • Medicine
  • Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine
  • 1991
TLDR
The effects of different administration of Salvia miltiorrhiza and heparin on ATIII and alpha 2-M in 102 patients with cor pulmonale were studied and the treatment combining SM intravenous drip withHeparin vapour inhalation is an efficient therapy of anticoagulation on the patients with Cor pulmonales. Expand
[Effect of Salvia miltiorrhiza on serum lipid peroxide, superoxide dismutase of the patients with coronary heart disease].
  • Z. Xing, X. Zeng, C. Yi
  • Medicine
  • Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • 1996
TLDR
It is suggested that Salvia miltiorrhiza could be regarded as a good exogenous scavenger of oxygen free radical. Expand
[Antioxidative effect of three water-soluble components isolated from Salvia miltiorrhiza in vitro].
TLDR
The antioxidative effect of three water-soluble components isolated from Salvia miltiorrhiza suggest that the three components have strong antilipoperoxidant activity in vitro, which may be partly through scavenging O2-.. Expand
Chinese herbs and warfarin potentiation by ‘Danshen’
TLDR
A case of danshen‐induced overcoagulation with severe and dangerous abnormalities of clotting in a patient with rheumatic heart disease is reported. Expand
[Effect of acetylsalvianolic acid A on platelet function].
  • W. Yu, L. Xu
  • Chemistry, Medicine
  • Yao xue xue bao = Acta pharmaceutica Sinica
  • 1994
TLDR
In ex vivo experiments with ADP, collagen, and AA as inducers, ASAA was also shown to inhibit platelet aggregation remarkably, and seemed to suggest that ASAA may be a widely effective inhibitor of platelet function. Expand
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
TLDR
Expansion of the structure-activity relationship to include anacardic acids, 6-(8'Z,11'Z-heptadecadienyl)- and 6-E-hexadecatrienyl)-salicylic acids from leaves of Anacardium spondias, and other fatty acids demonstrated that at least one cis double bond was essential for inhibitory activity, and that fatty acids containing two or three cis double bonds were optimal. Expand
Herbal medicine for the treatment of cardiovascular disease: clinical considerations.
TLDR
Clinicians must inquire about such health practices for cardiac disease and be informed about the potential for benefit and harm, and continuing research is necessary to elucidate the pharmacological activities of the many herbal remedies now being used to treat cardiovascular diseases. Expand
[Platelet aggregation inhibitors from Salvia miltiorrhiza Bunge].
TLDR
Related tricyclic diterpenoids such as miltirone and ferruginol were also found to have the same activity and were named △~1-dehydromiltir one and △-1- dehydrotanshinone Ⅱ_A. Expand
...
1
2
3
...