Interaction between TAK1–TAB1–TAB2 and RCAN1–calcineurin defines a signalling nodal control point

@article{Liu2009InteractionBT,
  title={Interaction between TAK1–TAB1–TAB2 and RCAN1–calcineurin defines a signalling nodal control point},
  author={Qinghang Liu and Jennifer A Caldwell Busby and Jeffery D Molkentin},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={154-161}
}
The calcium-activated protein phosphatase calcineurin is controlled by regulator of calcineurin (RCAN) in organisms ranging from yeast to mammals. Here we performed a yeast two-hybrid screen with RCAN1 as bait, identifying TAK1 binding protein 2 (TAB2) as an interacting partner. TAB2 interacted directly with RCAN1 in vitro and in vivo, recruiting TAK1, TAB1 and calcineurin, forming a macromolecular signalling complex. Overexpression of TAK1 and TAB1, or active TAK1ΔN, promoted direct… CONTINUE READING

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