Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.

@article{Jiang2003InteractionBS,
  title={Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.},
  author={Tianyun Jiang and Y. J. Qiu},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 18},
  pages={
          15789-93
        }
}
Activation of Akt by growth factors is a multistep process. Here, we provide evidence that tyrosine kinase Src is directly associated with Akt through the interaction between its SH3 domain and a conserved proline-rich motif (PXXP) in the C-terminal regulatory region of Akt. Substitution of the proline residues Pro-424 and Pro-427 by alanines results in loss of Akt activity and phosphorylation induced by the epidermal growth factor (EGF), possibly because these mutations disrupt the interaction… CONTINUE READING

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