Interaction between S100P and the anti-allergy drug cromolyn.

  title={Interaction between S100P and the anti-allergy drug cromolyn.},
  author={Srinivasa R. Penumutchu and Ruey Hwang Chou and Chin Yu},
  journal={Biochemical and biophysical research communications},
  volume={454 3},
The S100P protein has been known to mediate cell proliferation by binding the receptor for advanced glycation end products (RAGE) to activate signaling pathways, such as the extracellular regulated kinase (ERK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways. S100P/RAGE signaling is involved in a variety of diseases, such as cancer, metastasis, and diabetes. Cromolyn is an anti-allergy drug that binds S100P to block the interaction between S100P and RAGE. In… CONTINUE READING
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