Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats

@article{Rosado2012InteractionBN,
  title={Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats},
  author={Eugenio Rosado and A. Rodr{\'i}guez-Vilarrupla and J. Gracia-Sancho and Montserrat Moncl{\'u}s and J. Bosch and J. Garc{\'i}a-Pag{\'a}n},
  journal={Journal of Cellular and Molecular Medicine},
  year={2012},
  volume={16},
  pages={2461 - 2470}
}
Reduced intrahepatic nitric oxide (NO) bioavailability and increased cyclooxygenase‐1 (COX‐1)‐derived vasoconstrictor prostanoids modulate the hepatic vascular tone in cirrhosis. We aimed at investigating the reciprocal interactions between NO and COX in the hepatic endothelium of control and cirrhotic rats. NO bioavailability (DAF‐FM‐DA staining), superoxide (O2−) content (DHE staining), prostanoid production (PGI2 and TXA2 by enzyme immunoassays) as well as COX expression (Western Blot), were… Expand
Extracellular histones disarrange vasoactive mediators release through a COX‐NOS interaction in human endothelial cells
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