Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.

@article{Yang1978InteractionBN,
  title={Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.},
  author={Chung S Yang and F S Strickhart and L P Kicha},
  journal={Biochimica et biophysica acta},
  year={1978},
  volume={509 2},
  pages={326-37}
}
Solubilized NADPH-cytochrome P-450 reductase has been purified from liver microsomes of phenobarbital-treated rats. When added to microsomes, the reductase enhances the monoxygenase, such as aryl hydrocarbon hydroxylase, ethoxycoumarin O-dealkylase, and benzphetamine N-demethylase, activities. The enhancement can be observed with microsomes prepared from… CONTINUE READING