Interaction between Mouse Adenovirus Type 1 and Cell Surface Heparan Sulfate Proteoglycans

@inproceedings{Lenaerts2012InteractionBM,
  title={Interaction between Mouse Adenovirus Type 1 and Cell Surface Heparan Sulfate Proteoglycans},
  author={Liesbeth Lenaerts and Wim van Dam and Leentje Persoons and Lieve M J Naesens},
  booktitle={PloS one},
  year={2012}
}
Application of human adenovirus type 5 (Ad5) derived vectors for cancer gene therapy has been limited by the poor cell surface expression, on some tumor cell types, of the primary Ad5 receptor, the coxsackie-adenovirus-receptor (CAR), as well as the accumulation of Ad5 in the liver following interaction with blood coagulation factor X (FX) and subsequent… CONTINUE READING