Interaction between Mnk2 and CBCVHL ubiquitin ligase E3 complex

  title={Interaction between Mnk2 and CBCVHL ubiquitin ligase E3 complex},
  author={Pingzhang Wang and Xin Wang and Feng Wang and Tian Tian Cai and Ying Luo},
  journal={Science in China Series C},
MAP kinase-interacting kinase-2 (Mnk2) is one of the downstream kinases activated by MAP kinases. It phosphorylates the eukaryotic initiation factor 4E (elF4E), although the role of elF4E phosphorylation and the role of Mnk2 in the process of protein translation are not well understood. Except for elF4E, other physiological substrates of Mnk2 are still unidentified. To look for these unidentified substrates and to reveal the physiological function of Mnk2, we performed a yeast two-hybrid… 
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Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta.
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The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C*
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The structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF complex suggests that Cul1 may contribute to catalysis through the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supported by Cul1 mutations designed to eliminate the rigidity of the scaffold.
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The composition of Cul3‐based ligases to the well‐defined SCF and ECS ligases is compared and BTB‐domain‐containing proteins may bridge the cullin to the substrate in a single polypeptide.