Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches.

@article{Rebekah2017InteractionBM,
  title={Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches.},
  author={Prasoona K Rebekah and Sunitha Tella and Srinadh Buragadda and Muni Kumari Tiruvatturu and Jyothy Akka},
  journal={Birth defects research},
  year={2017},
  volume={109 13},
  pages={1020-1029}
}
BACKGROUND Neural tube defects (NTDs) are caused by the failure of neural tube formation which occurs during early embryonic development. NTDs are the most severe and leading cause of fetal mortality. Serine hydroxymethyl transferase (SHMT1) provides one-carbon units necessary for embryogenesis and defects in one-carbon production result in specific… CONTINUE READING