Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk.

@article{RodrguezRodrguez2009InteractionBH,
  title={Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk.},
  author={Eloy Rodr{\'i}guez-Rodr{\'i}guez and Ignacio Mateo and Jon Infante and Javier Llorca and In{\'e}s Garc{\'i}a-Gorostiaga and Jos{\'e} Luis V{\'a}zquez-Higuera and P{\'a}scual Sanchez-Juan and Jos{\'e} Berciano and Onofre Combarros},
  journal={Brain research},
  year={2009},
  volume={1280},
  pages={166-71}
}
A number of studies suggest that increased cellular cholesterol levels induce high amyloid beta (Abeta) production, which is central to the pathogenesis of Alzheimer's disease (AD). In the brain, glial cells have hydroxy-methylglutaryl-coenzyme A reductase (HMGCR) as the major rate-limiting enzyme in the novo synthesis of cholesterol, which once synthesized, is secreted via the cholesterol transporter ABCA1. Overexpression of HMGCR in concert with underexpression of ABCA1 would result in… CONTINUE READING
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