Interaction between HERC1 and M2-type pyruvate kinase.

  title={Interaction between HERC1 and M2-type pyruvate kinase.},
  author={Francesc R. Garcia-Gonzalo and Cristina Cruz and Purificaci{\'o}n Mu{\~n}oz and Sybille Mazurek and Erich Eigenbrodt and Francesc Ventura and Ramon Bartrons and Jos{\'e} Luis S{\'a}nchez de la Rosa},
  journal={FEBS letters},
  volume={539 1-3},
HERC proteins are characterized by having one or more RCC1-like domains as well as a C-terminal HECT domain in their amino acid sequences. This has led researchers to suggest that they may act as both guanine nucleotide exchange factors and E3 ubiquitin ligases. Here we describe a physical interaction between the HECT domain of HERC1, a giant protein involved in intracellular membrane traffic, and the M2 isoform of glycolytic enzyme pyruvate kinase (M2-PK). Partial colocalization of endogenous… CONTINUE READING