Interaction between HERC1 and M2‐type pyruvate kinase

@article{GarciaGonzalo2003InteractionBH,
  title={Interaction between HERC1 and M2‐type pyruvate kinase},
  author={Francesc R. Garcia-Gonzalo and C. Cruz and Purificaci{\'o}n Mu{\~n}oz and Sybille Mazurek and Erich Eigenbrodt and Francesc Ventura and Ramon Bartrons and Jose Luis Rosa},
  journal={FEBS Letters},
  year={2003},
  volume={539}
}
HERC proteins are characterized by having one or more RCC1‐like domains as well as a C‐terminal HECT domain in their amino acid sequences. This has led researchers to suggest that they may act as both guanine nucleotide exchange factors and E3 ubiquitin ligases. Here we describe a physical interaction between the HECT domain of HERC1, a giant protein involved in intracellular membrane traffic, and the M2 isoform of glycolytic enzyme pyruvate kinase (M2‐PK). Partial colocalization of endogenous… Expand
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References

SHOWING 1-10 OF 117 REFERENCES
HERC3 binding to and regulation by ubiquitin
TLDR
Observations indicate a fine regulation of HERC3 and suggest a role in vesicular traffic and ubiquitin‐dependent processes. Expand
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
TLDR
The crystal structure of the E6AP hect domain bound to the UbcH7 ubiquitin-conjugating enzyme (E2) reveals the determinants of E2-E3 specificity and provides insights into the transfer of ubiquitIn from the E2 to the E3. Expand
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
TLDR
It is proposed that other proteins with a Sec7 domain regulate different members of the ART family, including Geal, which is a large protein containing a domain of homology with Sec7, another yeast protein that is also involved in secretion. Expand
Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain
TLDR
It is proposed that the heme-binding cytochrome b5 domain served as a template for the evolution of membrane-associated binding pockets for non-heme ligands in MAPRs. Expand
The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.
TLDR
Phylogenetic analysis reveals that the HERC ancestor emerged in nematodes and that the family expanded throughout evolution, indicating strong evolutionary cohesions. Expand
HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells
TLDR
Data show for the first time that a functionally active HECT ubiquitin ligase exhibits a tightly controlled cytosolic level under inflammatory conditions in endothelial cells. Expand
A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.
TLDR
The present results suggest that Ceb1 may play a critical role when its expression and the CDK activity are upregulated by inactivation of p53 and RB. Expand
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
TLDR
Investigations of HPV-16 E7 mutants and the nononcogenic HPV-11 subtype suggest that the interaction of HPV's E7 with M2-PK may be linked to the transforming potential of the viral oncoprotein. Expand
DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion
TLDR
Downregulation of endogenous Del GEF in HeLa cells induced increased extracellular secretion of proteoglycans indicating a possible role for DelGEF in the secretion process. Expand
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture
TLDR
How knowledge of individual domain function has provided insight into the physiological roles of the Nedd4 proteins is discussed and recent results that suggest discrete functions for individual family members are described. Expand
...
1
2
3
4
5
...