Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.

@article{Zhao2007InteractionBG,
  title={Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.},
  author={Xinyan Zhao and Bo Zheng and Yanfang Huang and Dan Yang and Shoshana D. Katzman and Chawnshang Chang and Deborah J Fowell and Wei-ping Zeng},
  journal={Journal of immunology},
  year={2007},
  volume={179 12},
  pages={8297-304}
}
Th2 cytokine expression is dependent on the transcription factor GATA-3. However, the molecular interactions of GATA-3 leading to Th2 cytokine gene activation have not been well characterized. Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3. When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5. Conversely, Pias1 siRNA down… CONTINUE READING

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