Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use.

@article{Blomeyer2008InteractionBC,
  title={Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use.},
  author={Dorothea Blomeyer and Jens Treutlein and Guenter Esser and Martin H. Schmidt and Gunter Schumann and Manfred Laucht},
  journal={Biological psychiatry},
  year={2008},
  volume={63 2},
  pages={146-51}
}
BACKGROUND Recent animal research suggests that alterations in the corticotropin releasing hormone receptor 1 (CRHR1) may lead to heavy alcohol use following repeated stress. The aim of this study was to examine interactions between two haplotype-tagging single nucleotide polymorphisms (SNPs) covering the CRHR1 gene and adverse life events on heavy drinking in adolescents. METHODS Data were available from the Mannheim Study of Children at Risk, an ongoing cohort study of the long-term outcome… CONTINUE READING
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