Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell.

@article{Ohashi2007InteractionBC,
  title={Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell.},
  author={Rina Ohashi and Fumiyuki Takahashi and Ri Cui and Masakata Yoshioka and Tao Gu and Shinichi Sasaki and Shigeru Tominaga and Kazuto Nishio and Kenneth K Tanabe and Kazuhisa Takahashi},
  journal={Cancer letters},
  year={2007},
  volume={252 2},
  pages={225-34}
}
CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2… CONTINUE READING
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