Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide

@inproceedings{RezaeiGhaleh2011InteractionBA,
  title={Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide},
  author={Nasrollah Rezaei-Ghaleh and Erika Andreetto and Li-Mei Yan and Aphrodite Kapurniotu and Markus Zweckstetter},
  booktitle={PloS one},
  year={2011}
}
Assembly of amyloid-beta peptide (Aβ) into cytotoxic oligomeric and fibrillar aggregates is believed to be a major pathologic event in Alzheimer's disease (AD) and interfering with Aβ aggregation is an important strategy in the development of novel therapeutic approaches. Prior studies have shown that the double N-methylated analogue of islet amyloid polypeptide (IAPP) IAPP-GI, which is a conformationally constrained IAPP analogue mimicking a non-amyloidogenic IAPP conformation, is capable of… CONTINUE READING