Interaction between ATM protein and c-Abl in response to DNA damage

@article{Shafman1997InteractionBA,
  title={Interaction between ATM protein and c-Abl in response to DNA damage},
  author={Timothy D. Shafman and Kum Kum Khanna and Padmini Kedar and Kevin J. Spring and Sergei Kozlov and Tim Yen and Karen Hobson and Magtouf Gatei and Ning Zhang and Dianne Josephine Watters and Mark Egerton and Yosef Shiloh and Surender Kharbanda and Donald Kufe and Martin F. Laving},
  journal={Nature},
  year={1997},
  volume={387},
  pages={520-523}
}
The gene mutated in the autosomal recessive disorder ataxia telangiectasia (AT), designated ATM (for 'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase-like enzymes that are involved in cell-cycle control, meiotic recombination, telomere length monitoring and DNA-damage response1–4. Previous results have demonstrated that AT cells are hypersensitive to ionizing radiation5–7 and are defective at the Gl/S checkpoint after radiation damage8–10. Because cells lacking the… CONTINUE READING

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