Interaction between A b Peptide and a Synuclein : Molecular Mechanisms in Overlapping Pathology of Alzheimer ’ s and Parkinson ’ s in Dementia with Lewy Body Disease

@inproceedings{Mandal2006InteractionBA,
  title={Interaction between A b Peptide and a Synuclein : Molecular Mechanisms in Overlapping Pathology of Alzheimer ’ s and Parkinson ’ s in Dementia with Lewy Body Disease},
  author={Pravat K. Mandal and Jay W. Pettegrew and Eliezer Masliah and Ronald L. Hamilton and Ratna Mandal},
  year={2006}
}
Amyloidogenic proteins (Ab peptide) in Alzheimer’s disease (AD) and alpha-synuclein (a-Syn) in Parkinson’s disease (PD) are typically soluble monomeric precursors, which undergo remarkable conformational changes and culminate in the form of aggregates in diseased condition. Overlap of clinical and neuropathological features of both AD and PD are observed in dementia with Lewy body (DLB) disease, the second most common form of dementia after AD. The identification of a 35-amino acid fragment of… CONTINUE READING
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