Interaction at end-plate receptors between different choline derivatives

@article{Castillo1957InteractionAE,
  title={Interaction at end-plate receptors between different choline derivatives},
  author={Jos{\'e} del Castillo and Bernard Katz},
  journal={Proceedings of the Royal Society of London. Series B - Biological Sciences},
  year={1957},
  volume={146},
  pages={369 - 381}
}
  • J. Castillo, B. Katz
  • Published 7 May 1957
  • Biology, Chemistry
  • Proceedings of the Royal Society of London. Series B - Biological Sciences
Interaction between different choline derivatives has been studied by applying them simultaneously to a motor end-plate and recording the resulting changes in the membrane potential of the muscle fibre. Choline potentiates the depolarizing effect of acetylcholine (Ach) when applied in normal Ringer. Decamethonium has a ‘diphasic’ action, initial depression of the Ach effect being followed by more prolonged potentiation. When these experiments are made after treating the muscle with an esterase… 

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