Interaction and localization of the retinitis pigmentosa protein RP2 and NSF in retinal photoreceptor cells.

@article{Holopainen2010InteractionAL,
  title={Interaction and localization of the retinitis pigmentosa protein RP2 and NSF in retinal photoreceptor cells.},
  author={Juha M. Holopainen and Christiana L. Cheng and Laurie L. Molday and Gurp Johal and Jonathan E. Coleman and Frank M. Dyka and Theresa Hii and Jinhi Ahn and Robert S Molday},
  journal={Biochemistry},
  year={2010},
  volume={49 35},
  pages={
          7439-47
        }
}
RP2 is a ubiquitously expressed protein encoded by a gene associated with X-linked retinitis pigmentosa (XLRP), a retinal degenerative disease that causes severe vision loss. Previous in vitro studies have shown that RP2 binds to ADP ribosylation factor-like 3 (Arl3) and activates its intrinsic GTPase activity, but the function of RP2 in the retina, and in particular photoreceptor cells, remains unclear. To begin to define the role of RP2 in the retina and XLRP, we have conducted biochemical… CONTINUE READING

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