Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis.

@article{Bhattacharya2010InteractionAO,
  title={Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis.},
  author={Monolekha Bhattacharya and Ashis Biswas and Amit Das},
  journal={Biochimie},
  year={2010},
  volume={92 3},
  pages={263-72}
}
TcrX/Y is one of the twelve two component system (TCS) present in Mycobacterium tuberculosis. We have investigated the TcrX/Y interaction by in silico studies, pull down assay, radioactive phosphotransfer, surface plasmon resonance as well as crosstalk analysis of TcrY with TcrA - a non-cognate response regulator. Sequence alignment of TcrY with other histidine kinases revealed His256 as the residue responsible for autophosphorylation. The modeled structure of TcrX/Y was docked with each other… CONTINUE READING

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