Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure.

@article{Wang2003InteractionAN,
  title={Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure.},
  author={Wei Wang and Suparoek Jittikanont and Sandor A. Falk and Ping Li and Lili Feng and Patricia E Gengaro and Brian D. Poole and Russell P Bowler and Brian J. Day and James D. Crapo and Robert Schrier},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={284 3},
  pages={F532-7}
}
Acute renal failure (ARF) during sepsis is associated with increased nitric oxide (NO) and oxygen radicals, including superoxide (O(2)(-)). Because O(2)(-) reacts with NO in a rapid manner, it plays an important role in modulating NO levels. Therefore, scavenging of O(2)(-) by superoxide dismutase (SOD) may be critical for preserving NO bioavailability. In mice, substantial renal extracellular SOD (EC-SOD) expression implies its important role in scavenging O(2)(-) in the kidney. We… CONTINUE READING

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