Interaction Study between Digoxin and a Preparation of Hawthorn (Crataegus oxyacantha)

@article{Tankanow2003InteractionSB,
  title={Interaction Study between Digoxin and a Preparation of Hawthorn (Crataegus oxyacantha)},
  author={Roberta M. Tankanow and Helen R. Tamer and Daniel Streetman and Scott G. Smith and J. Welton and Thomas M. Annesley and Keith D. Aaronson and Barry E. Bleske},
  journal={The Journal of Clinical Pharmacology},
  year={2003},
  volume={43}
}
Hawthorn, an herbal supplement, is currently being evaluated for the treatment of heart failure. The flavonoid components of hawthorn may be responsible for hawthorn's beneficial effects in the treatment of heart failure. However, these components may also affect P‐glycoprotein function and cause interactions with drugs that are P‐glycoprotein substrates, such as digoxin, which is also used to treat heart failure. Therefore, the purpose of this study was to determine the effect of hawthorn on… 
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  • Medicine
    The British journal of general practice : the journal of the Royal College of General Practitioners
  • 2006
TLDR
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TLDR
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Adverse-Event Profile of Crataegus Spp.
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The herbal preparations seem to be well tolerated and no interaction is known so far, but the data on a possible decrease on blood pressure are inconclusive.
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