Interaction Studies Between Indomethacin Nanocrystals and PEO/PPO Copolymer Stabilizers

  title={Interaction Studies Between Indomethacin Nanocrystals and PEO/PPO Copolymer Stabilizers},
  author={Peng Liu and Tapani Viitala and Alma Kartal-Hodzic and Huamin Liang and Timo Laaksonen and Jouni Hirvonen and L. Peltonen},
  journal={Pharmaceutical Research},
The lack of effective screening methods and systemic understanding of interaction mechanisms complicates the stabilizer selection process for nanocrystallization. This study focuses on the efficiency of stabilizers with various molecular compositions and structures to stabilize drug nanocrystals. Five structurally different polymers were chosen as stabilizers for indomethacin nanocrystals. The affinity of polymers onto drug surfaces was measured using surface plasmon resonance (SPR) and contact… CONTINUE READING
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