Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis.
@article{Colizzi2015InteractionBF, title={Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis.}, author={Marco Colizzi and Conrad Osamede Iyegbe and John Powell and Gianluca Ursini and Annamaria Porcelli and Aurora Bonvino and Paolo Taurisano and Raffaella Romano and Rita Masellis and Giuseppe Blasi and Craig Morgan and Katherine J. Aitchison and Valeria Mondelli and Sonija Luzi and Anna Kolliakou and Anthony S. David and Robin M. Murray and Alessandro Bertolino and Marta di Forti}, journal={Schizophrenia bulletin}, year={2015}, volume={41 5}, pages={ 1171-82 } }
Both cannabis use and the dopamine receptor (DRD2) gene have been associated with schizophrenia, psychosis-like experiences, and cognition. However, there are no published data investigating whether genetically determined variation in DRD2 dopaminergic signaling might play a role in individual susceptibility to cannabis-associated psychosis. We genotyped (1) a case-control study of 272 patients with their first episode of psychosis and 234 controls, and also from (2) a sample of 252 healthy…
73 Citations
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References
SHOWING 1-10 OF 69 REFERENCES
Cannabis, COMT and psychotic experiences
- Psychology, MedicineBritish Journal of Psychiatry
- 2011
Findings argue against the widely held belief that the relative risk of developing psychosis following use of cannabis is dependent upon variation within catechol-methyl-transferase (COMT), and suggest that this harm is subgroup specific in the absence of robust evidence of replication.
Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users
- Medicine, PsychologyBiological Psychiatry
- 2012
Interaction between COMT haplotypes and cannabis in schizophrenia: A case-only study in two samples from Spain
- Psychology, MedicineSchizophrenia Research
- 2011
AKT1 Moderation of Cannabis-Induced Cognitive Alterations in Psychotic Disorder
- Psychology, MedicineNeuropsychopharmacology
- 2011
It is suggested that long-term changes in cognition may mediate the risk-increasing effect of the AKT1 × cannabis interaction on psychotic disorder, and cannabis use before onset of psychosis may have long-lasting effects on measures of sustained attention, even in the absence of current use.
Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
- Psychology, MedicineArchives of general psychiatry
- 2011
Genetic variation in AKT1 may mediate both short-term as well as longer-term effects on psychosis expression associated with use of cannabis, possibly through a mechanism of cannabinoid-regulatedAKT1/GSK-3 signaling downstream of the dopamine D(2) receptor.
COMT val158met and 5-HTTLPR Genetic Polymorphisms Moderate Executive Control in Cannabis Users
- BiologyNeuropsychopharmacology
- 2013
It is found that daily cannabis use is not associated with executive function deficits; and COMT val158met and 5-HTTLPR polymorphisms moderate the link between cannabis use and executive performance.
Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction
- Psychology, MedicineBiological Psychiatry
- 2005
Dopaminergic Function in Cannabis Users and Its Relationship to Cannabis-Induced Psychotic Symptoms
- Psychology, MedicineBiological Psychiatry
- 2014
The environment and schizophrenia: the role of cannabis use.
- Psychology, MedicineSchizophrenia bulletin
- 2005
Evidence suggests that cannabis is a component cause in the development and prognosis of psychosis, in which mechanisms of gene-environment interaction are most likely to explain this association.
Functional Genetic Variation of the Cannabinoid Receptor 1 and Cannabis Use Interact on Prefrontal Connectivity and Related Working Memory Behavior
- Biology, PsychologyNeuropsychopharmacology
- 2015
The results indicate that the deleterious effects of cannabis use are more evident on a specific genetic background related to its receptor expression.