Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)

@inproceedings{Yang2013InteractionAB,
  title={Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)},
  author={Shumei Yang and Hsiang-Ming Chen and Li-Ching Lee and Shih-Han Huang and Chih-Hsin Lin and Guan-Chiun Lee and Cheng-Kang Lee and Guey-Jen Lee-Chen},
  year={2013}
}
Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine-expanded TATA box binding protein (TBP), a general transcription initiation factor. TBP interacts with other protein factors, including high mobility group box 1 (HMGB1), to regulate gene expression. In this study, we examined the effect of TBP Q-tract length on HMGB1 binding using recombinant HMGB1 and N-terminal TBP/Q20~61 proteins. The intracellular association of HMGB1 with TBP was first confirmed by using a… 
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