Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)

  title={Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)},
  author={Shumei Yang and Hsiang-Ming Chen and Li-Ching Lee and Shih-Han Huang and Chih-Hsin Lin and Guan-Chiun Lee and Cheng-Kang Lee and Guey-Jen Lee-Chen},
Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine-expanded TATA box binding protein (TBP), a general transcription initiation factor. TBP interacts with other protein factors, including high mobility group box 1 (HMGB1), to regulate gene expression. In this study, we examined the effect of TBP Q-tract length on HMGB1 binding using recombinant HMGB1 and N-terminal TBP/Q20~61 proteins. The intracellular association of HMGB1 with TBP was first confirmed by using a… 

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High Mobility Group Protein 1 Interacts Specifically with the Core Domain of Human TATA Box-binding Protein and Interferes with Transcription Factor IIB within the Pre-initiation Complex*

A general involvement of HMG1 at the early stages of polymerase II transcription that may result in subtle activation or repression of individual genes is suggested.

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  • M. Štros
  • Biology
    Biochimica et biophysica acta
  • 2010

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