Interaction – Epidemiology’s Brinkmanship

  title={Interaction – Epidemiology’s Brinkmanship},
  author={A. Morabia},
  journal={Epidemiologic Methods},
  pages={73 - 77}
  • A. Morabia
  • Published 2014
  • Medicine
  • Epidemiologic Methods
Something is missing in VanderWeele and Knol’s extensive and remarkable review of the assessment and interpretation of interactions (VanderWeele and Knol, 2015). At which point does the analysis of interaction become incompatible with epidemiology? In an extreme scenario in which multiple exposures interact with one another, including all higher degree interactions, that is, in a model that is saturated with interactions, there is a different solution for each individual, and the basic tools of… Expand
Interactions and Complexity: Goals and Limitations
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The findings add to the evidence suggesting that low testosterone and high estradiol may be associated greater risks of IR and T2D by interacting with overall and central obesity in adult men. Expand
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Concepts of interaction.
It is proposed that synergy (or its negative counterpart, antagonism) between two or more causes of disease ought to be evaluated in reference to a specific yardstick, with effect defined as excess risk. Expand
A Tutorial on Interaction
Abstract In this tutorial, we provide a broad introduction to the topic of interaction between the effects of exposures. We discuss interaction on both additive and multiplicative scales using risks,Expand
Epidemiology's 350th Anniversary: 1662-2012.
In an extremely convulsed century, these profound and convergent upheavals produced the equivalent of a cultural big bang, which opened a new domain of knowledge acquisition based on population thinking and group comparisons. Expand
Biologic synergism and parallelism.
  • J. Darroch
  • Medicine
  • American journal of epidemiology
  • 1997
In epidemiologic studies of two binary exposure factors, much attention has been given to the concept of synergism of the factors, but it is pointed out here that, unfortunately, both models incorporate the strong assumption that there is no parallelism. Expand
Gene-environment interaction: definitions and study designs.
  • R. Ottman
  • Biology, Medicine
  • Preventive medicine
  • 1996
This overview presents a simple definition of gene-environment interaction and suggests study designs for detecting it, and five biologically plausible models are described for the relations between genotypes and environmental exposures, in terms of their effects on disease risk. Expand
An epidemiologic approach to gene‐environment interaction
Five plausible models are described for relationships between genetic and environmental effects, and an example of a simple mendelian disorder that fits each model is given. Expand
The history of confounding
SummaryConfounding is a basic problem of comparability-and therefore has always been present in science. Originally a plain English word, it acquired more specific meanings in epidemiologic thinkingExpand
The design of case-control studies: the influence of confounding and interaction effects.
  • P. Smith, N. Day
  • Mathematics, Medicine
  • International journal of epidemiology
  • 1984
If one aim of a study is to detect interactions, the size of the study will have to be at least four times larger than if attention were confined to detecting main effects of the same magnitude. Expand
Epidemiologic interactions, complexity, and the lonesome death of Max von Pettenkofer.
  • A. Morabia
  • Medicine
  • American journal of epidemiology
  • 2007
Max von Pettenkofer's complex mode of thinking sank into oblivion even though, in hindsight, germ-environment interactions are more appropriate than is bacteriology alone for explaining the occurrence of cholera epidemics in populations. Expand
On the Distinction Between Interaction and Effect Modification
The analytic procedures for obtaining estimates of effect modification parameters and interaction parameters using marginal structural models are compared and contrasted and a characterization is given of the settings in which interaction and effect modification coincide. Expand