Interacting signals in the control of hepcidin expression

  title={Interacting signals in the control of hepcidin expression},
  author={Deepak Darshan and Gregory J Anderson},
The amount of iron in the plasma is determined by the regulated release of iron from most body cells, but macrophages, intestinal enterocytes and hepatocytes play a particularly important role in this process. This cellular iron efflux is modulated by the liver-derived peptide hepcidin, and this peptide is now regarded as the central regulator of body iron homeostasis. Hepcidin expression is influenced by systemic stimuli such as iron stores, the rate of erythropoiesis, inflammation, hypoxia… CONTINUE READING