Interacting roles of nitric oxide and ATP in the pulmonary circulation of the rat.

@article{Hassssian1995InteractingRO,
  title={Interacting roles of nitric oxide and ATP in the pulmonary circulation of the rat.},
  author={H Hass{\'e}ssian and Geoffrey Burnstock},
  journal={British journal of pharmacology},
  year={1995},
  volume={114 4},
  pages={846-50}
}
1. The potentiating effect of NG-nitro-L-arginine methyl ester, (L-NAME) a nitric oxide synthesis inhibitor, on responses of the rat pulmonary vascular pressure (PVP) to purinoceptor agonists was examined. 2. At a constant flow of 23 ml min-1 the PVP was 22.4 +/- 2.5 mmHg (n = 15), and treatment with 100 microM L-NAME for 15 min was without effect on the PVP. After the tone was raised with 28 nmol 9,11-dideoxy-11 alpha, 9 alpha-epoxymethano-prostaglandin F2 alpha (U-46619), the PVP was 29.4… CONTINUE READING

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