Interacting roles of immune mechanisms and viral load in the pathogenesis of crimean-congo hemorrhagic fever.

@article{Saksida2010InteractingRO,
  title={Interacting roles of immune mechanisms and viral load in the pathogenesis of crimean-congo hemorrhagic fever.},
  author={Ana Saksida and Darja Duh and Branka Wraber and Isuf Dedushaj and Salih Ahmeti and Tatjana Av{\vs}i{\vc}-Županc},
  journal={Clinical and vaccine immunology : CVI},
  year={2010},
  volume={17 7},
  pages={1086-93}
}
Until now, the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) has not been well described. However, it has been hypothesized that it could be a result of the direct injury of virus-infected tissues in combination with the indirect effects of host immune responses, including cytokines. To shed more light on the role of viral load and cytokines, differential influences of CCHF virus (CCHFV) RNA load, antibody response, and cytokine production on severity and outcome of the disease were… CONTINUE READING