Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.

@article{Chen2012InteractingEO,
  title={Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.},
  author={Jieyin Chen and Xianglin Li and Matt McGue},
  journal={Genes, brain, and behavior},
  year={2012},
  volume={11 8},
  pages={
          958-65
        }
}
There is a strong etiological link between brain-derived neurotrophic factor and depression, but the neurocellular mechanisms and gene-environment interactions remain obscure. This study investigated whether one functional polymorphism in the brain-derived neurotrophic factor gene (BDNF Val66Met) modulates the influence of stressful life events on adolescent depressive symptoms. A total of 780 pairs of ethnic Han Chinese adolescent twins, 11-17 years of age, were randomly assigned to one of two… CONTINUE READING

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