Inter-molecular crosslinking activity is engendered by the dimeric form of transglutaminase 2

Abstract

Transglutaminase 2 (TGase 2) catalyzes a crosslink between protein bound-glutamine and -lysine. We proposed the mechanism of TGase 2 activation depends on conformation change from unfolded monomer to unfolded dimer. We found that TGase 2 has temperature-sensitive conformation change system at 30 °C. Small-angle X-ray scattering analysis showed that the… (More)
DOI: 10.1007/s00726-016-2293-1

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