Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay.

  title={Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay.},
  author={Zolt{\'a}n Ker{\'e}nyi and Zsuzsanna M{\'e}rai and L{\'a}szl{\'o} Hiripi and Anna Hangy{\'a}n{\'e} Benkovics and P{\'e}ter Gyula and Christophe Lacomme and Endre Barta and Ferenc Nagy and D{\'a}niel Silhavy},
  journal={The EMBO journal},
  volume={27 11},
Nonsense-mediated mRNA decay (NMD) is a quality control system that degrades mRNAs containing premature termination codons. Although NMD is well characterized in yeast and mammals, plant NMD is poorly understood. We have undertaken the functional dissection of NMD pathways in plants. Using an approach that allows rapid identification of plant NMD trans factors, we demonstrated that two plant NMD pathways coexist, one eliminates mRNAs with long 3'UTRs, whereas a distinct pathway degrades mRNAs… CONTINUE READING