Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome

@inproceedings{Illingworth2015InterindividualVC,
  title={Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome},
  author={Robert S. Illingworth and Ulrike Gruenewald-Schneider and Dina De Sousa and Shaun Webb and Cara Merusi and Alastair R. W. Kerr and Keith D. James and Colin A. Smith and Robert Walker and Robert Andrews and Adrian Bird},
  booktitle={Nucleic acids research},
  year={2015}
}
The possibility that alterations in DNA methylation are mechanistic drivers of development, aging and susceptibility to disease is widely acknowledged, but evidence remains patchy or inconclusive. Of particular interest in this regard is the brain, where it has been reported that DNA methylation impacts on neuronal activity, learning and memory, drug addiction and neurodegeneration. Until recently, however, little was known about the 'landscape' of the human brain methylome. Here we assay 1.9… CONTINUE READING
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