Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology.

@article{Harro2010InterindividualDI,
  title={Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology.},
  author={Jaanus Harro},
  journal={Pharmacology & therapeutics},
  year={2010},
  volume={125 3},
  pages={402-22}
}
Susceptibility to affective disorders is individually different, and determined both by genetic variance and life events that cause significant differences in the CNS structure and function between individual subjects. Therefore it is plausible that search for the inter-individual differences in endophenotypes that mediate the effects of causal factors, both genetic and environmental, will reveal the substrates for vulnerability, help to clarify pathogenetic mechanisms, and possibly aid in… CONTINUE READING