Inter-domain interactions of TDP-43 as decoded by NMR.

Abstract

TDP-43 inclusions have been found in ∼97% ALS as well as an increasing spectrum of other neurodegenerative diseases including Alzheimer's. TDP-43 contains an ubiquitin-like fold, two RRMs and a prion-like domain, but whether they interact with each other remains unknown due to being intrinsically aggregation-prone. Nevertheless, this knowledge is pivotal to… (More)
DOI: 10.1016/j.bbrc.2016.03.158

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