Inter- and intrasubject variabilities in the pharmacokinetics of rufloxacin after single oral administration to healthy volunteers.

@article{Imbimbo1991InterAI,
  title={Inter- and intrasubject variabilities in the pharmacokinetics of rufloxacin after single oral administration to healthy volunteers.},
  author={Bruno Pietro Imbimbo and G P Broccali and Marina Cesana and Francesca Crema and Giuseppe Attardo-Parrinello},
  journal={Antimicrobial agents and chemotherapy},
  year={1991},
  volume={35 2},
  pages={390-3}
}
Rufloxacin is a new long-acting, once-daily quinolone antibacterial agent. We evaluated inter- and intrasubject variations in pharmacokinetics of rufloxacin following oral administration of 400 mg (two capsules) under controlled conditions, at an interval of 2 weeks (periods I and II), to 12 healthy male subjects. Plasma and urine samples were collected up to 48 h after drug administration. Plasma drug levels determined by bioassay were higher than those measured by high-performance liquid… CONTINUE READING

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