Inter- and intraspecies metabolite exchange promotes virulence of antibiotic-resistant Staphylococcus aureus.

@article{Hammer2014InterAI,
  title={Inter- and intraspecies metabolite exchange promotes virulence of antibiotic-resistant Staphylococcus aureus.},
  author={Neal D. Hammer and James E Cassat and Michael J. Noto and Lisa J Lojek and Ashley D. Chadha and Jonathan E. Schmitz and Clarence Buddy Creech and Eric P Skaar},
  journal={Cell host & microbe},
  year={2014},
  volume={16 4},
  pages={531-7}
}
Adaptations that enable antimicrobial resistance often pose a fitness cost to the microorganism. Resistant pathogens must therefore overcome such fitness decreases to persist within their hosts. Here we demonstrate that the reduced fitness associated with one resistance-conferring mutation can be offset by community interactions with microorganisms harboring alternative mutations or via interactions with the human microbiota. Mutations that confer antibiotic resistance in the human pathogen… CONTINUE READING
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Antibiotic resistance threats in the United States, 2013

  • CDC
  • (Atlanta, GA: Centers for Disease Control and…
  • 2013
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