Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3

@inproceedings{Ferdous2012InterHomologCA,
  title={Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3},
  author={Maheen Ferdous and James D Higgins and Kim Osman and Christophe Lambing and Elisabeth Roitinger and Karl Mechtler and Susan J Armstrong and R. Michael Perry and M{\'o}nica Pradillo and Nieves Cu{\~n}ado and F Christopher H Franklin},
  booktitle={PLoS genetics},
  year={2012}
}
In this study we have analysed AtASY3, a coiled-coil domain protein that is required for normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein compromises chromosome axis formation and results in reduced numbers of meiotic crossovers (COs). Although the frequency of DNA double-strand breaks (DSBs) appears moderately reduced in Atasy3-1, the main recombination defect is a reduction in the formation of COs. Immunolocalization studies in wild-type meiocytes… CONTINUE READING
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