Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies.

@article{Spitzer2000IntentionalIO,
  title={Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies.},
  author={Thomas R. Spitzer and Steven McAfee and Robert Sackstein and Christine Colby and Han Chong Toh and Pratik S. Multani and Susan L. Saidman and D W Weyouth and Frederic Preffer and C. M. Poliquin and Amanda S Foley and B Cox and Dawn M. Andrews and David H Sachs and Megan Sykes},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2000},
  volume={6 3A},
  pages={309-20}
}
Mixed lymphohematopoietic chimerism can be induced in mice with bone marrow transplantation (BMT) after a nonmyeloablative preparative regimen that includes cyclophosphamide, anti-T-cell antibody therapy, and thymic irradiation. These mixed chimeras are resistant to the induction of graft-versus-host disease (GVHD) after delayed donor leukocyte infusions (DLIs), despite a potent lymphohematopoietic graft-versus-host reaction that converts the mixed chimeric state to a full donor one. Based on… CONTINUE READING
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