Intention-to-treat analysis with treatment discontinuation and missing data in clinical trials.

@article{Little2015IntentiontotreatAW,
  title={Intention-to-treat analysis with treatment discontinuation and missing data in clinical trials.},
  author={Roderick J. A. Little and Shan Kang},
  journal={Statistics in medicine},
  year={2015},
  volume={34 16},
  pages={2381-90}
}
Motivated by a recent National Research Council study, we discuss three aspects of the analysis of clinical trials when participants prematurely discontinue treatments. First, we distinguish treatment discontinuation from missing outcome data. Data collection is often stopped after treatment discontinuation, but outcome data could be recorded on individuals after they discontinue treatment, as the National Research Council study recommends. Conversely, outcome data may be missing for… CONTINUE READING
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