Intensive insulin therapy in the medical ICU.

  title={Intensive insulin therapy in the medical ICU.},
  author={Greet Van den Berghe and Alexander Wilmer and Greet Hermans and Wouter Meersseman and Pieter Jozef Wouters and Ilse Milants and Eric van Wijngaerden and Herman J. Bobbaers and Roger Bouillon},
  journal={The New England journal of medicine},
  volume={354 5},
BACKGROUND Intensive insulin therapy reduces morbidity and mortality in patients in surgical intensive care units (ICUs), but its role in patients in medical ICUs is unknown. METHODS In a prospective, randomized, controlled study of adult patients admitted to our medical ICU, we studied patients who were considered to need intensive care for at least three days. On admission, patients were randomly assigned to strict normalization of blood glucose levels (80 to 110 mg per deciliter [4.4 to 6… 

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