Intensive insulin therapy and pentastarch resuscitation in severe sepsis.

@article{Brunkhorst2008IntensiveIT,
  title={Intensive insulin therapy and pentastarch resuscitation in severe sepsis.},
  author={Frank Brunkhorst and Christoph Engel and Frank Bloos and Andreas Meier‑Hellmann and Maximilian Ragaller and Norbert Weiler and Onnen Moerer and Matthias Gruendling and Michael Oppert and Stefan Grond and Derk Olthoff and Ulrich Jaschinski and Stefan John and Rolf Rossaint and Tobias Welte and Martin Schaefer and P Kern and Evelyn Kuhnt and Michael Kiehntopf and Christiane S. Hartog and Charles Natanson and Markus W. Loeffler and Konrad Reinhart},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 2},
  pages={
          125-39
        }
}
BACKGROUND The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. METHODS In a multicenter, two-by-two factorial trial, we randomly assigned patients with severe sepsis to receive either intensive insulin therapy to maintain euglycemia or conventional insulin therapy and either 10% pentastarch, a low-molecular… 

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