Intensive granulocyte and monocyte adsorption versus intravenous prednisolone in patients with severe ulcerative colitis: an unblinded randomised multi-centre controlled study.

@article{Hanai2008IntensiveGA,
  title={Intensive granulocyte and monocyte adsorption versus intravenous prednisolone in patients with severe ulcerative colitis: an unblinded randomised multi-centre controlled study.},
  author={Hiroyuki Hanai and Takayuki Iida and Ken Takeuchi and Fumitoshi Watanabe and Yasuhiko Maruyama and Masanobu Kageoka and Kentarou Ikeya and Masami Yamada and Masataka Kikuyama and Yasushi Iwaoka and Kazuhisa Hirayama and Shinji Nagata and Yoshihiko Sato and Yoshisuke Hosoda},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2008},
  volume={40 6},
  pages={433-40}
}
BACKGROUND AND AIM Several uncontrolled studies have reported on the efficacy of adsorptive depletion of peripheral blood granulocytes and monocytes/macrophages (GM) in patients with moderate or severe ulcerative colitis. This study was to compare the efficacy and safety of intensive GMA with intensive intravenous prednisolone in patients with severe ulcerative colitis. METHODS Seventy patients with clinical activity index 10-23 were randomly assigned to intensive GMA with the Adacolumn, at 2… CONTINUE READING

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