Intensive chemotherapy with cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin's disease.

@article{Reece1991IntensiveCW,
  title={Intensive chemotherapy with cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin's disease.},
  author={Donna E. Reece and Michael Barnett and Joseph M. Connors and Randall N. Fairey and Joseph W. Fay and John P. Greer and Geoffrey P. Herzig and Roger H. Herzig and Hans G. Klingemann and Charles Fred Lemaistre},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1991},
  volume={9 10},
  pages={1871-9}
}
Fifty-six consecutive patients with advanced Hodgkin's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high-dose cyclophosphamide (7.2 g/m2), carmustine (BCNU; 0.6 g/m2), and etoposide (VP16-213; 2.4 g/m2) (CBV) followed by autologous bone marrow transplantation (BMT). Prior combination chemotherapy had failed in all the patients, and all but five had been previously treated with both mechlorethamine, vincristine, procarbazine, and… CONTINUE READING

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Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
EtoposideNo subtypeVP-16
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
EtoposideHas lab numberVP-16
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Hodgkin DiseaseMay be treated byCarmustine
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
Intensive chemotherapy with cyclophosphamide , carmustine , and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin 's disease .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
PrednisoneIs component of chemotherapy regimenMOPP protocol
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
VincristineIs component of chemotherapy regimenMOPP protocol
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Prior combination chemotherapy had failed in all the patients , and all but five had been previously treated with both mechlorethamine , vincristine , procarbazine , and prednisone ( MOPP ) and doxorubicin , bleomycin , and vinblastine with or without dacarbazine ( ABV[D ] ) .
Fifty - six consecutive patients with advanced Hodgkin 's disease considered incurable with further conventional chemotherapy were entered into a protocol that included high - dose cyclophosphamide ( 7.2 g / m2 ) , carmustine ( BCNU ; 0.6 g / m2 ) , and etoposide ( VP16 - 213 ; 2.4 g / m2 ) ( CBV ) followed by autologous bone marrow transplantation ( BMT ) .
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