Intensive care of patients with acute liver failure: Recommendations of the U.S. Acute Liver Failure Study Group

@article{Stravitz2007IntensiveCO,
  title={Intensive care of patients with acute liver failure: Recommendations of the U.S. Acute Liver Failure Study Group},
  author={R. Todd Stravitz and Andreas H. Kramer and Timothy J. Davern and A. Obaid S. Shaikh and Stephen Hugh Caldwell and Ravindra L. Mehta and Andres T. Blei and Robert John Fontana and Brendan M. Mcguire and Lorenzo Rossaro and Alastair D. Smith and William M. Lee},
  journal={Critical Care Medicine},
  year={2007},
  volume={35},
  pages={2498-2508}
}
Objective:To provide a uniform platform from which to study acute liver failure, the U.S. Acute Liver Failure Study Group has sought to standardize the management of patients with acute liver failure within participating centers. Methods:In areas where consensus could not be reached because of divergent practices and a paucity of studies in acute liver failure patients, additional information was gleaned from the intensive care literature and literature on the management of intracranial… Expand
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265 Citations
Highly Influential Citations
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Background Citations
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Paper Mentions

Interventional Clinical Trial
Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury
This Phase 2a clinical study is designed to provide data on OCR-002 in patients with acute liver failure/acute liver injury (ALF/ALI) in regard to: - safety and tolerability… Expand
ConditionsAcute Liver Failure, Acute Liver Injury
InterventionDrug
University of Texas Southwestern Medical Center
June 2012 - February 2017

265 Citations

Citation Type

Citation Type

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This large cohort study found that despite similar causes and severity of ALF among patients referred to specialty centers from 1998 to 2013, the proportion of patients listed for liver transplantation decreased and survival improved among those who did not receive a transplant as well asThose who did. Expand
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Alongside similarities in principles of care of ALF patients, major areas of divergence were present in key areas of diagnosis, monitoring, treatment and decision to transplant. Expand
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Recent research shows that use of dynamic prognostic models is better for selecting patients undergoing liver transplantation and timely transplant can save life of patients with ALF with poor prognostic factors. Expand
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[Intensive care of patients with acute liver failure].
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The article defines the diseases, discusses etiological factors, treatment strategies, indications for referral to the transplantation unit at Rikshospitalet and prognostic factors of importance, and identifies literature identified through a non-systematic search in PubMed. Expand
Invasive intracranial pressure monitoring is a useful adjunct in the management of severe hepatic encephalopathy associated with pediatric acute liver failure*
  • P. Kamat, S. Kunde, +5 authors J. Fortenberry
  • Medicine
  • Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2012
TLDR
In this series of patients, intracranial pressure monitoring had a low complication rate and was associated with a high survival rate despite severe hepatic encephalopathy and cerebral edema in the setting of pediatric acute liver failure. Expand
Management of Hepatic Encephalopathy
  • J. Frontera
  • Medicine
  • Current Treatment Options in Neurology
  • 2014
Opinion statementHepatic encephalopathy management varies depending on the acuity of liver failure. However, in patients with either acute or chronic liver failure five basic steps in management are… Expand
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The definitive goals of care are confirming the initial diagnosis, initiating appropriate etiology-directed therapy, monitoring for further hepatic decompensation, supporting homeostasis to facilitate hepatic regeneration, and preventing complications. Expand
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TLDR
Using a pathophysiological‐guided approach to the management of ALF associated complications is essential to optimizing patient care and identifying the underlying etiology and initiating symptomatic care is imperative. Expand
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