Intensive care management of acute liver failure

@article{Auzinger2008IntensiveCM,
  title={Intensive care management of acute liver failure},
  author={Georg Auzinger and Julia A. Wendon},
  journal={Current Opinion in Critical Care},
  year={2008},
  volume={14},
  pages={179–188}
}
Purpose of reviewThe mortality of acute liver failure remains unacceptably high and liver transplantation is the only effective treatment available to date. This review focuses on new research developments in the field and aims to provide a pragmatic organ-based treatment approach for liver failure patients requiring intensive care support. Recent findingsThe pathophysiological basis for cerebral edema formation in acute liver failure continued to be the focus of various investigations. In-vivo… 
Current concepts in acute liver failure.
TLDR
The main aspects of ALF are reviewed, including the definition, diagnosis and complications, and the standard-of-care strategies and recent advances in the treatment are described.
An overview of acute liver failure: Managing rapid deterioration
TLDR
An overview of the current medical and nursing strategies for managing acute liver failure is provided, which is associated with a high mortality and morbidity, despite advances in intensive care and management.
Management of acute liver failure
TLDR
Advances in the intensive care management of patients with ALF are highlighted that have contributed to a marked improvement in their overall survival over the past 20 years, including therapies that limit the extent of liver injury and maximize the likelihood of spontaneous recovery.
[Intensive care of patients with acute liver failure].
  • L. Ytrebø, P. Klepstad
  • Medicine
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 2010
TLDR
The article defines the diseases, discusses etiological factors, treatment strategies, indications for referral to the transplantation unit at Rikshospitalet and prognostic factors of importance, and identifies literature identified through a non-systematic search in PubMed.
Hepatic Failure
The progression of liver disease can cause several physiologic derangements that may precipitate hepatic failure and require admission to an intensive care unit. The underlying pathology may be
Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure.
TLDR
Recent research shows that use of dynamic prognostic models is better for selecting patients undergoing liver transplantation and timely transplant can save life of patients with ALF with poor prognostic factors.
Management of Cerebral Edema in Acute Liver Failure
TLDR
This review particularly provides a practical focus on general management of the patient with established cerebral edema as well as specific intracranial pressure‐lowering strategies, and a brief summary into the pathophysiology and risk factors for developing cerebralEdema in the context of acute liver failure.
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.
TLDR
A viral model of AHF is developed by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease, and it displays biochemical and histological characteristics, and clinical features that resemble those in human AHF.
Extracorporeal liver support
TLDR
The future development of liver support systems may provide different combinations of new adsorbents, integrated regional citrate anticoagulation and eventual substitution of irreversibly damaged albumin.
Acute Liver Failure.
TLDR
An evidence base for practice is emerging for supportive care, and a better understanding of the pathophysiology of the disorder, especially in relation to hepatic encephalopathy, will probably soon lead to further improvements in survival rates.
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