Intensive care management of acute liver failure

@article{Auzinger2008IntensiveCM,
  title={Intensive care management of acute liver failure},
  author={Georg Auzinger and Julia A. Wendon},
  journal={Current Opinion in Critical Care},
  year={2008},
  volume={14},
  pages={179–188}
}
Purpose of reviewThe mortality of acute liver failure remains unacceptably high and liver transplantation is the only effective treatment available to date. This review focuses on new research developments in the field and aims to provide a pragmatic organ-based treatment approach for liver failure patients requiring intensive care support. Recent findingsThe pathophysiological basis for cerebral edema formation in acute liver failure continued to be the focus of various investigations. In-vivo… 
Current concepts in acute liver failure.
An overview of acute liver failure: Managing rapid deterioration
TLDR
An overview of the current medical and nursing strategies for managing acute liver failure is provided, which is associated with a high mortality and morbidity, despite advances in intensive care and management.
Management of acute liver failure
TLDR
Advances in the intensive care management of patients with ALF are highlighted that have contributed to a marked improvement in their overall survival over the past 20 years, including therapies that limit the extent of liver injury and maximize the likelihood of spontaneous recovery.
[Intensive care of patients with acute liver failure].
  • L. Ytrebø, P. Klepstad
  • Medicine
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 2010
TLDR
The article defines the diseases, discusses etiological factors, treatment strategies, indications for referral to the transplantation unit at Rikshospitalet and prognostic factors of importance, and identifies literature identified through a non-systematic search in PubMed.
Hepatic Failure
TLDR
In this chapter, the definition, clinical manifestations, workup, and management of acute and chronic liver failure and the general principles of treatment of these patients are discussed.
Management of Cerebral Edema in Acute Liver Failure
TLDR
This review particularly provides a practical focus on general management of the patient with established cerebral edema as well as specific intracranial pressure‐lowering strategies, and a brief summary into the pathophysiology and risk factors for developing cerebralEdema in the context of acute liver failure.
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure.
TLDR
A viral model of AHF is developed by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease, and it displays biochemical and histological characteristics, and clinical features that resemble those in human AHF.
Extracorporeal liver support
TLDR
The future development of liver support systems may provide different combinations of new adsorbents, integrated regional citrate anticoagulation and eventual substitution of irreversibly damaged albumin.
Acute Liver Failure.
TLDR
An evidence base for practice is emerging for supportive care, and a better understanding of the pathophysiology of the disorder, especially in relation to hepatic encephalopathy, will probably soon lead to further improvements in survival rates.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 80 REFERENCES
Predictive value of arterial ammonia for complications and outcome in acute liver failure
TLDR
Arterial ammonia at presentation is predictive of outcome and can be used for risk stratification, and levels of partial pressure of ammonia were equally correlated with outcome.
The clinical importance of adrenal insufficiency in acute hepatic dysfunction
TLDR
Adrenal dysfunction assessed by the SST is common in AHD and may contribute to hemodynamic instability and mortality and correlates with severity of illness.
Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy
  • J. Vaquero, R. Fontana, A. Blei
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2005
TLDR
The risk of intracranial hemorrhage following ICP monitoring may have decreased in the last decade, but major complications are still present, and future studies of the impact of intrACranial hypertension should also focus on long‐term neurological recovery from ALF.
Incidence of lung injury in acute liver failure: diagnostic role of extravascular lung water index
TLDR
This study tried to study the incidence and outcome of ALI in a heterogeneous group of patients with ALF, and aimed to investigate the role of extravascular lung water index (EVLWI) measurements in diagnosis and management of ALi in liver failure.
Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
TLDR
Ammonia is an independent risk factor for the development of both HE and ICH, and its combination with ammonia increased specificity and accuracy and improved the prediction of HE.
Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure
TLDR
Intracranial pressure monitoring represents a potentially important tool in the preoperative and intraoperative management of comatose patients with fulminant hepatic failure and warrants further study.
...
1
2
3
4
5
...