Intensity of malaria transmission, antimalarial-drug use and resistance in Uganda: what is the relationship between these three factors?

@article{Talisuna2002IntensityOM,
  title={Intensity of malaria transmission, antimalarial-drug use and resistance in Uganda: what is the relationship between these three factors?},
  author={Ambrose Otau Talisuna and Peter Langi and Nathan Bakyaita and Thomas G. Egwang and Theonest K. Mutabingwa and William Watkins and Eric van Marck and Umberto D'Alessandro},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={2002},
  volume={96 3},
  pages={310-7}
}
We studied (in 1998 and 1999) some factors that may be linked to the spread of chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) resistance in 7 discrete communities in Uganda. Exposure to malaria infection was measured by parasitological surveys in children aged 1-9 years, drug use by community surveys and drug resistance by in-vivo tests on children aged 6-59 months with clinical malaria. CQ use was inversely related to parasite prevalence (r = -0.85, P = 0.01). CQ and SP treatment failure… CONTINUE READING